ANTICANCER DRUGS OR ANTINEOPLASTICS

DRUGS ACTING DIRECTLY ON CELLS (CYTOTOXIC DRUGS)

 

1. Alkylating Agents

a. Nitrogen mustards

Melphalan

Mechlorethamine (Mustine HCl)

Cyclophosphamide

Ifosfamide

Chlorambucil

b. Ethylenimine

Thio-TEPA

c. Alkyl sulfonate

Busulfan

d. Nitrosoureas

Carmustine

Lomustine

e. Triazine

Dacarbazine

Temozolomide

f. Methyl hydrazine

Procarbazine

 

2. Antimetabolites

a. Folate antagonist

Methotrexate

b. Purine Antagonist

6-Mercaptopurine

6-Thioguanine

Azathioprine

Fludarabine

c. PyrimidineAntagonist

5-Fluorouracil

Cytarabine

Capecitabine

 

3. Microtubule  Damaging Agents

a. Vinca alkaloids

Vincristine

Vinblastine

b. Taxanes

Paclitaxel

Docetaxel

c. Others

Estramustine

 

4. EpipodophylloToxin(Topoisomerase-2 inhibitor)

Etoposide

 

5. CamptothecinAnalogues (Topoisomerase-1 inhibitor)

Topotecan

Irinotecan

 

6. Antibiotics

Actinomycin D

Doxorubicin

Daunorubicin

Epirubicin

Mitoxantrone

Bleomycins

Mitomycin C

 

7. Miscellaneous

Hydroxyurea

L-Asparaginase

Tretinoin

Arsenic trioxide

 

 

 

TARGETED DRUGS

a. Tyrosine protein kinase inhibitors

Imatinib

Nilotinib

 

b. EGF receptor inhibitors

Gefitinib

Erlotinib

Cetuximab

 

c. Angiogenesis Inhibitors

Sunitinib

Bevacizumab

 

d. Proteosome inhibitor

Bortezomib

 

e. Monoclonal Antibody

Rituximab

 

 

DRUGS ALTERING HORMONAL MILIEU

 

1. Glucocorticoids

Prednisolone and others

 

2. Estrogens

Fosfestrol

Ethinylestradiol

 

3. Selective estrogen receptor modulators

Tamoxifen

Toremifene

 

4. Selective estrogen receptor down regulator

Fulvestrant

 

5. Aromatase inhibitors

Letrozole

Anastrozole

Exemestane

 

6. Antiandrogen

Flutamide

Bicalutamide

 

7. 5-α  reductase Inhibitors

Finasteride

Dutasteride

 

8. GnRH analogues

Naferelin

Triptorelin

 

9. Progestins

Hydroxyprogesterone caproate