APPSC Pharmacist 2021 Syllabus

1. Introduction of different dosage forms.
2. Introduction to Pharmacopoeias with special reference to the Indian Pharmacopoeia.
3. Metrology: Systems of weights and measures. Calculations including conversion from one to another
system.
4. Packing of Pharmaceuticals:
5. Size reduction
6. Size separation:
7. Mixing and Homogenisation:
8. Clarification and Filtration
9. Extraction and Galenicals
10. Heat processes Evaporation:
11. Distillation:
12. Introduction to drying processes:
13. Sterilization: Aseptic techniques.
14. Processing of Tablets, Capsules:
16. Study of immunological products

1.General discussion on the following inorganic compounds
(A) Acids, bases and buffers
(B) Antioxidants:
(C) Gastrointestinal agents–(i) Acidifying agents (ii) Antacids (iii) Protectives and Adsorbents (iv) Saline
Cathartics
(D) Topical Agents-(i) Protectives (ii) Antimicrobials and Astringents (iii) Sulphur and its compounds
(iv) Astringents (E) Dental Products (F) Inhalants (G) Respiratory stimulants (H) Expectorants and Emetics
(I) Antidotes
2. Major Intra and Extracellular electrolytes3. Inorganic Official compounds
4.Radio pharmaceuticals and Contrast media
5.Quality control of Drugs and Pharmaceuticals
6.Identification tests

1. Definition, history and scope of Pharmacognosy including indigenous system of medicine.
2. classification of drugs of natural origin.
3. Adulteration and drug evaluation; significance of Pharmacopoeial standards.
4. Brief outline of occurrence, distribution, outline of isolation, identification tests, therapeutic
effects and pharmaceutical applications of alkaloids, terpenoids, glycosides, volatile oils, tannins and
resins.
5. Occurrence, distribution, organoleptic evaluation, chemical constituents including tests
(a) Laxatives: Aloes, Rhuburb, Castor oil, Ispaghula, Senna.
(b) Cardiotonics-Digitalis, Arjuna.
(c) Carminatives & G.I. regulators-Umbelliferous fruits, Coriander, Fennel, Ajowan, Cardamom Ginger,
Black pepper, Asafoetida, Nutmeg, Cinnamon, Clove.
(d) Astringents- Catechu.
(e) Drugs acting on nervous system-Hyoscyamus, Belladonna, Aconite, Ashwagandha, Ephedra,
Opium, Cannabis, Nux vomica.
(f) Antihypertensives-Rauwolfia.
(g) Antitussives-Vasaka, Tolu balsam, Tulsi.
(h) Antirheumatics-Guggul, Colchicum.
(i) Antitumour-Vinca.
(j) Antileprotics-Chaulmoogra Oil.
(k) Antidiabetics -Pterocarpus, Gymnema, Sylvestro.
(l) Diuretics-Gokhru, Punarrnava.
(m) Antidysentrics-Ipecacuanha
(n) Antiseptics and disinfectants Benzoin, Myrrh. Nim, curcuma.
(o) Antimalarials – Cinchona.
(p) Oxytocics-Ergot.
(q) Vitamines-Shark liver Oil and Amla.
(r) Enzymes-Papaya, Diastase, Yeast.
(s) Perfumes and flavouring agents-Peppermint Oil, Lemon Oil, Orange Oil, Lemon grass Oil,
Sandalwood.
(t) Pharmaceutical aids-Honey, Arachis Oil, Starch, Kaolin, Pectin, Olive oil, Lanolin, Beeswax, Acacia,
Tragacanth, Sodium alginate, Agar, Guar gum, Gelatin.
(u) Miscellaneous-Liquorice, Garlic, Picrorhiza, Dioscorea, Linseed, Shatavari, Shankhapusphi,
Pyrethrum, Tobacco.
6. Collection and preparation of crude drug for the market as exemplified by Ergot, opium, Rauwolfia,
Digitalis, Senna.
7. Study of source, preparation and identification of fibres used in sutures and surgical dressingscotton, silk, wool and regenerated fibre.
8. Gross anatomical studies of Senna, Datura, Cinnamon, Cinchona, Fennel, Clove, Ginger, Nux vomica
& Ipecacuanha.

1. Introduction to biochemistry.
2. Brief chemistry and role of proteins,
3. Brief chemistry and role of Carbohydrates, carbohydrate metabolism.
4. Brief chemistry and role of Lipids
5. Brief chemistry and role of Vitamins and Coenzymes.
6. Role of minerals and water in life processes.
7. Enzymes :
8. Brief concept of normal and abnormal metabolism of proteins, carbohydrates and lipids.
9. Introduction to pathology of blood and urine.

1. Scope of Anatomy and Physiology. various terms used in Anatomy
2. Structure of cell, function of its components.
3. Elementary tissues i.e epithelial tissue, muscular tissue, connective tissue and nervous tissue.
4. Structure and function of skeleton. Classification of joints and their function, Joint disorder.
5. Composition of blood, functions of blood elements. Blood group and coagulation of blood.
6. Name and functions of lymph glands.
7. Structure and functions of various parts of the heart.
8. Various parts of respiratory system
9. Various parts of urinary system
10. Structure of skeletal muscle. Physiology of muscle contraction
11. Various parts of central nervous system, brain and its parts, functions and reflex action. Anatomy and
Physiology of autonomic nervous system.
12. Sense organs: organs of taste, smell, ear, eye and skin. Physiology of pain.
13. Digestive system; names of the various parts of digestive system and their functions. Structure and
functions of liver, physiology of digestion and absorption.
14. Endocrine glands and Hormones.
15. Reproductive system -Physiology and Anatomy of Reproductive system.

1. Concept of health: Definition of physical health, mental health, social health, spiritual health
determinants of health, indicators of health, concept of disease, natural history of diseases, the disease
agents, concept of prevention of diseases.
2. Nutrition and health:
3. Demography and family planning: Demography cycle, fertility, family planning, contraceptive methods,
behavioural methods, natural family planning method, chemical method, mechanical methods, hormonal
contraceptives, population problem of India.
4. First aid : Emergency treatment in shock, snake-bite, burns poisoning, heart disease, fractures and
resuscitation methods. Elements of minor surgery and dressings.
5. Environment and health-Sources
6. Fundamental principles of microbiology
7. Communicable diseases :
(a) Respiratory infections: Chicken pox, measles. Influenza, diphtheria, whooping cough and
tuberculosis.
(b) Intestinal infections: Poliomyelitis. Hepatitis. Cholera. Typhoid, Food poisoning, Hookworm infection.
(c) Arthropod borne infections-plague, Malaria, Filariasis.
(d) Surface infections-Rabies, Trachoma, Tetanus, Leprosy.
(e) Sexually transmitted diseases —Syphilis. Gonorrhoea. AIDS.
8. Non-communicable diseases-Causative agents, prevention, care and control; Cancer, Diabetes,
Blindness, Cardiovascular diseases.

1. Dispensing Pharmacy:
(i) Prescriptions
(ii) Incompatibilities in Prescriptions-Study of various types of incompatibilities-physical, chemical and
therapeutic.
(iii) Posology: Dose and Dosage of drugs, Factors influencing dose, Calculations of doses on the basis of
age, sex and surface area. Veterinary doses.
(i) Powders- 1. Dispensing Pharmacy:
(i) Prescriptions
(ii) Incompatibilities in Prescriptions-Study of various types of incompatibilities-physical, chemical and
therapeutic.
(iii) Posology: Dose and Dosage of drugs, Factors influencing dose, Calculations of doses on the basis of
age, sex and surface area. Veterinary doses.
(i) Powders- (ii) Liquid Oral Dosage Forms:
(a). Monophasic: Liquids for internal administration
Liquids for external administration or used on mucus membranes.
Mixtures and concentrates
Gargles
Syrups
Mouth washes
Throat-paints
Douches
Elixirs
Ear Drops
Nasal drops & Sprays Liniments
Lotions.
(b) Biphasic Liquid Dosage Forms:
(i) Suspension
(ii) Emulsions
(iii) Semi-Solid Dosage Forms:
(a) Ointments:
(b) Pastes
(c) Jellies
(d) An elementary study of poultice.
(e) Suppositories and pessaries
(iv) Dental and Cosmetic Preparations:
(v) Sterile Dosage Forms:
(a) Parenteral dosage forms:
(b) Sterility testing,
(c) Ophthalmic Products

1. Introduction to the nomenclature of organic chemical systems with particular reference to heterocyclic
system containing up to 3 rings.
2. The Chemistry of following Pharmaceutical organic compounds,
Antiseptics and Disinfectants
Sulfonamides
Antileprotic Drugs, Anti-tubercular Drugs
Antiamoebic and Anthelmintic Drugs
Antibiotics-Benzyl Penicillin* Gentamicin, Neomycin , Erythromycin , Tetracycline, Cephalosporins,
Griseofulvin , Chloramphenicol.
Antifungal agents
Antimalarial Drugs
CNS – Tranquilizers, Hypnotics, General Anaesthetics, Antidepressant Drugs, Analeptics, Anticonvulsants
ANS- Adrenergic Drugs, Adrenergic Antagoinst, Cholinergic Drugs, Cholinergic Antagonists
Diuretic Drugs
CVS- Cardiovascular Drugs, Hypoglycemic Agents, Coagulants and Anti-Coagulants, cardiac glycosides,
Antiarrhythmic antihypertensives & vitamins.
Local Anaesthetics Histamine and Anti-histaminic Agents
Analgesics and Anti-pyretics Non-steroidal anti-inflammatory Agents, Diagnostic Agents, Steroidal
Drugs-Anti- Neoplastic Drugs

1. Introduction to the nomenclature of organic chemical systems with particular reference to heterocyclic
system containing up to 3 rings.
2. The Chemistry of following Pharmaceutical organic compounds,
Antiseptics and Disinfectants
Sulfonamides
Antileprotic Drugs, Anti-tubercular Drugs
Antiamoebic and Anthelmintic Drugs
Antibiotics-Benzyl Penicillin* Gentamicin, Neomycin , Erythromycin , Tetracycline, Cephalosporins,
Griseofulvin , Chloramphenicol.
Antifungal agents
Antimalarial Drugs
CNS – Tranquilizers, Hypnotics, General Anaesthetics, Antidepressant Drugs, Analeptics, Anticonvulsants
ANS- Adrenergic Drugs, Adrenergic Antagoinst, Cholinergic Drugs, Cholinergic Antagonists
Diuretic Drugs
CVS- Cardiovascular Drugs, Hypoglycemic Agents, Coagulants and Anti-Coagulants, cardiac glycosides,
Antiarrhythmic antihypertensives & vitamins.
Local Anaesthetics Histamine and Anti-histaminic Agents
Analgesics and Anti-pyretics Non-steroidal anti-inflammatory Agents, Diagnostic Agents, Steroidal
Drugs-Anti- Neoplastic Drugs

1. Origin and nature of Pharmaceutical legislation in India, its scope and objectives. Evolution of the
“Concept of Pharmacy” as an integral part of the Health Care System.
2. Principles and significance of Professional Ethics.
3. Pharmacy Act,
4. The Drugs and Cosmetics Act,
5. The Drug and Magic Remedies
6. Narcotic Drugs and Psychotropic Substances Act,
7. Latest Drugs (Price Control) Order in force.
8. Poisons Act 1919 (as amended to date)
9. Medicinal and Toilet Preparations (Excise Duties) Act, 1995 (as amended to date)
10. Medical Termination of Pregnancy Act, 1971 (as amended to date)

1. Introduction-Trade, Industry and Commerce, Functions and subdivision of Commerce, Introduction of
Elements of Economics and Management.
2. Forms of Business Organisations.
3. Channels of Distribution.
4. Drug House Management5. Inventory Control6. Sales Promotion, Market Research, Salesmanship, qualities of a salesman, Advertising and
Window Display.
7. Recruitment, training, evaluation and compensation of the pharmacist.
8 Banking and Finance Service and functions of the bank, Finance Planning and sources of finance.

PART-I :HOSPITAL PHARMACY:
1. Hospitals Definition, Function, Classifications
2. Hospital Pharmacy:Hospital Pharmaceutical services.Location, Layout, Personnel and facilities
3. Drug Distribution system in Hospitals:
(a) Out-patient services
(b) In-patient services-(a) types of services (b) detailed discussion of unit Dose system, Floor ward stock
system, Satellite pharmacy services, Central sterile services, Bed Side Pharmacy.
4. Manufacturing:
Sterile manufacture-large and small volume parenterals
Non-sterile manufacture-Liquid orals, externals-bulk concentrates.
Procurement of stores and testing of raw materials.
5. Nomenclature and uses of surgical instruments and Hospital Equipments and health accessories.
6. P.T.C (Pharmacy Therapeutic Committee), Hospital Formulary System
7. Drug Information service and Drug Information Bulletin.
8. Surgical dressing like cotton, gauze, bandages and adhesive tapes
9. Application of computer
PART-II : CLINICAL PHARMACY.
1. Introduction to Clinical Pharmacy Practice-Definition, scope.
2. Modern dispensing aspects
3. Common daily terminology
4. Disease, manifestation and pathophysiology of diseases like Tuberculosis, Hepatitis, Rheumatoid
Arthritis, Cardiovascular diseases, Epilepsy, Diabetes, Peptic Ulcer, Hypertension.
5. Physiological parameters
6. Drug Interactions:Drug-drug interaction, Drug-food interaction.
7. Adverse Drug Reactions.:
8. Drugs in Clinical Toxicity-Introduction,
9. Drug dependences, Drug abuse, addictive drugs
10. Bioavailability of drugs