Beta-blockers are competitive antagonists that block the receptor sites for endogenous catecholamines (Adrenaline and Noradrenaline) on adrenergic beta receptors of sympathetic nervous system.
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NONSELECTIVE (β1 and β2)
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a. Without intrinsic sympathomimetic activity
Propranolol
Sotalol
Timolol
b. With intrinsic sympathomimetic activity
Pindolol
c. With additional α-blocking property
Labetalol
Carvedilol
2. CARDIOSELECTIVE (β1)
Metoprolol
Atenolol
Acebutolol
Bisoprolol
Esmolol
Betaxolol
Celiprolol
Nebivolol
GENERATION WISE CLASSIFICATION
1. First Generation (older, nonselective)
Propranolol
Timolol
Sotalol
Pindolol
2. Second Generation (β2 selective)
Metoprolol
Atenolol
Acebutolol
Bisoprolol
Esmolol
3. Third Generation (with additional α blocking and/ or vasodilator property)
Labetalol
Carvedilol
Celiprolol
Nabivolol
BETA ADRENERGIC BLOCKING AGENTS